Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis.
نویسندگان
چکیده
Tailoring steps are often important for the activity of mature antibiotics. Here, we report that novel decarboxylated FR-008/candicidin derivatives were obtained from the P450 monooxygenase gene fscP mutant of Streptomyces sp. strain FR-008. The toxicity of decarboxylated FR-008/candicidin derivatives has been shown to be greatly reduced compared to that of wild-type FR-008/candicidin.
منابع مشابه
Development of Streptomyces sp. FR-008 as an emerging chassis☆
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ورودعنوان ژورنال:
- Applied and environmental microbiology
دوره 75 6 شماره
صفحات -
تاریخ انتشار 2009